Huising Lab

Laboratory of Dr. Mark O. Huising, UC Davis

Selected Publications

2026

Figure from: Hart RG, Lee JJ, Zhai K, Lee S, Chauhan R, Hosseini A, Nguyen AD, Huising MO, 20 Hart RG, Lee JJ, Zhai K, Lee S, Chauhan R, Hosseini A, Nguyen AD, Huising MO, 2026. Somatostatin Receptors Shape Insulin and Glucagon Output within the Pancreatic Islet through Direct and Paracrine Effects. Diabetologia, in press.
BioRxiv.

2025

Figure from: Pourhosseinzadeh MS, Huang JL, Shin D, Hart RG, Framroze LY, Guillen JV, Sanchez Pourhosseinzadeh MS, Huang JL, Shin D, Hart RG, Framroze LY, Guillen JV, Sanchez J, Tirado RV, Unanwa K, Huising MO. 2024. Heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals and low-density Cx36 gap junctions.
Proceedings of the National Academy of Sciences USA, 122(38).

Figure from: Reininger L, Rehman M, Bouabcha A, Ferragne S, Tremblay C, Ethier M, Kimple ME, Reininger L, Rehman M, Bouabcha A, Ferragne S, Tremblay C, Ethier M, Kimple ME, Ghislain J,Sanchez J, Huising MO, Poitout V. 2025. Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.
BioRxiv.

2024

Figure from: Huang JL, Pourhosseinzadeh MS, Lee S, Krämer N, Guillen JV, Cinque NH, Aniceto P Huang JL, Pourhosseinzadeh MS, Lee S, Krämer N, Guillen JV, Cinque NH, Aniceto P, Momen AT, Koike S, Huising MO. 2024. Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice.
Nature Metabolidm 6(1):61-77.

Figure from: Noguchi GM, Castillo VC, Donaldson CJ, Flisher MR, Momen AT, Saghatelian A, Hui Noguchi GM, Castillo VC, Donaldson CJ, Flisher MR, Momen AT, Saghatelian A, Huising MO. 2024. Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice.
Journal of Endocrinology 261(3).

2023

Figure from: Rubio-Navarro A, Gómez-Banoy N, Stoll L, Dündar F, Mawla AM, Ma L, Cortada E, Zu Rubio-Navarro A, Gómez-Banoy N, Stoll L, Dündar F, Mawla AM, Ma L, Cortada E, Zumbo P, Li A, Reiterer M, Montoya-Oviedo N, Homan EA, Imai N, Gilani A, Liu C, Naji A, Yang B, Chi Nok Chong A, Cohen DE, Chen S, Cao J, Pitt GS, Huising MO, Betel D, Lo JC. 2023. A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes .
Nature Cell Biology, 25(4):565-578.

Figure from: Mawla AM, van der Meulen T, Huising MO. 2023. Chromatin accessibility differenc Mawla AM, van der Meulen T, Huising MO. 2023. Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers.
BMC Genomics 24, 202.

Dataset

2021

Figure from: Mawla AM, Huising MO. 2021. epiRomics: a multi-omics R package to identify and v Mawla AM, Huising MO. 2021. epiRomics: a multi-omics R package to identify and visualize enhancers.
bioRxiv.

Github Repository Link
Package Documentation
Aggregated Human Islet Shiny Browser Showcase

Figure from: Lee S, Zhang J, Saravanakumar S, Flisher MF, Grimm DR, van der Meulen T, Huisi Lee S, Zhang J, Saravanakumar S, Flisher MF, Grimm DR, van der Meulen T, Huising MO. 2021. Virgin beta cells at the neogenic niche proliferate normally and mature slowly.
Diabetes.

Figure from: Croze ML, Flisher MF, Guillaume A, Tremblay C, Noguchi GM, Granziera S, Vivot K, Croze ML, Flisher MF, Guillaume A, Tremblay C, Noguchi GM, Granziera S, Vivot K, Castillo VC, Campbell SA, Ghislain J, Huising MO, Poitout V. 2021. Free fatty-acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.
Molecular Metabolism, 101166:2212-8778.

2020

Figure from: Huising MO. 2020. Paracrine regulation of insulin secretion.Diabetologia, 63(10 Huising MO. 2020. Paracrine regulation of insulin secretion.
Diabetologia, 63(10): 2057-2063.

Figure from: Huang JL, Lee S, Hoek P, van der Meulen T, Van R, Huising MO. 2020. Genetic del Huang JL, Lee S, Hoek P, van der Meulen T, Van R, Huising MO. 2020. Genetic deletion of Urocortin 3 does not prevent functional maturation of beta cells.
Journal of Endocrinology, 246(1): 69-78.

2019

Figure from: Noguchi GM, Huising MO. 2019. Integrating the inputs that shape pancreatic islet Noguchi GM, Huising MO. 2019. Integrating the inputs that shape pancreatic islet hormone release.
Nature Metabolism, (1): 1189–1201.

Figure from: Mawla AM, Huising MO. 2019. Navigating the Depths and Avoiding the Shallows of P Mawla AM, Huising MO. 2019. Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes.
Diabetes, 68(7): 1380-1393.

Dataset

2018

Figure from: Huising MO, Lee S, van der Meulen T. 2018. Evidence for a Neogenic Niche at the Huising MO, Lee S, van der Meulen T. 2018. Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets.
BioEssays, 40(11):e1800119.

Featured Editorial in BioEssays.

Figure from: Huising MO, van Der Meulen T, Huang JL, Pourhosseinzadeh MS, Noguchi GM. 2018. T Huising MO, van Der Meulen T, Huang JL, Pourhosseinzadeh MS, Noguchi GM. 2018. The Difference δ-Cells Make in Glucose Control.
Physiology, 33(6):403-411

Featured Editorial in Physiology.

Figure from: Rorsman P, Huising MO. 2018. The somatostatin-secreting pancreatic δ-cell in hea Rorsman P, Huising MO. 2018. The somatostatin-secreting pancreatic δ-cell in health and disease.
Nature Reviews Endocrinology, 27(1):218-225.

Figure from: van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla AM, Huising MO. 2018. Artemether Does Not Turn α Cells into β Cells.
Cell Metabolism, 27(1):218-225.

2017

Figure from: van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, A van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO. 2017. Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.
Cell Metabolism, 25(4):911-926.

Dataset
2017/2018 UC Davis College of Biological Science Faculty Research Award

2016

Figure from: DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, va DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, van der Meulen T, Huising MO. 2016. Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets.
Molecular Metabolism, 5(7):449–458.

Dataset
Featured Editorial in Molecular Metabolism.

2015

Figure from: van der Meulen T, Donaldson CJ, Caceres E, Hunter AE, Cowing-Zitron C, Pound LD, van der Meulen T, Donaldson CJ, Caceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO. 2015 Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.
Nature Medicine, 21(7):769-776.

Dataset
Featured Editorial in Science Signaling.

Huising MO. 2015 Tuning to the right signal. Diabetologia, 58(6):1146-1148.

Figure from: van der Meulen T and Huising MO. 2015 Role of transcription factors in the trans van der Meulen T and Huising MO. 2015 Role of transcription factors in the transdifferentiation of pancreatic islet cells.
Journal of Molecular Endocrinology, 54(2):R103-117.

2014

Figure from: Benner C, van der Meulen T, Caceres E, Tigyi K, Donaldson CJ, Huising MO. 2014 T Benner C, van der Meulen T, Caceres E, Tigyi K, Donaldson CJ, Huising MO. 2014 The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.
BMC Genomics 15(1):620.

Dataset

Figure from: van der Meulen T, Huising MO. 2014 Maturation of Stem Cell-Derived Beta cells Gu van der Meulen T, Huising MO. 2014 Maturation of Stem Cell-Derived Beta cells Guided by the Expression of Urocortin 3.
The Review of Diabetic Studies, 11(1):115-132.

2012

Figure from: van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO. 2012 Urocortin van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO. 2012 Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells.
PLoS ONE, 7(12):e52181.

2011

Figure from: Huising MO, Pilbrow A, Matsumoto M, van der Meulen T, Park H, Donaldson CJ, Vaug Huising MO, Pilbrow A, Matsumoto M, van der Meulen T, Park H, Donaldson CJ, Vaughan JM, Lee, SL, Vale WW. 2011 Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2a in MIN6 insulinoma cells and rodent islets.
Endocrinology, 152(1):138-150.

2010

Figure from: Huising MO, van der Meulen T, Vaughan JM, Donaldson CJ, Park H, Billestrup N, Va Huising MO, van der Meulen T, Vaughan JM, Donaldson CJ, Park H, Billestrup N, Vale WW. 2010 Corticotropin releasing factor receptor 1 (CRFR1) is expressed on pancreatic b cells, promotes b cell proliferation and potentiates insulin secretion in an incretin-like manner.
Proceedings of the National Academy of Sciences USA, 107(2):912-917.

Featured in the Wall Street Journal.

2008

Figure from: Huising MO, Vaughan JM, Shah SH, Grillot KL, Donaldson CJ, Rivier J, Flik G, Val Huising MO, Vaughan JM, Shah SH, Grillot KL, Donaldson CJ, Rivier J, Flik G, Vale WW. 2008 Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1.
Journal of Biological Chemistry, 283(14):8902-8912.